Proton/Deuterium Magnetic Resonance Imaging of Rodents at 9.4T Using Birdcage Coils
Citations Over TimeTop 19% of 2021 papers
Abstract
The purpose of the present study was to fabricate a volume coil for proton/deuterium magnetic resonance imaging (MRI) in rodents at 9.4 T. Two birdcage radiofrequency (RF) coils have been designed for proton/deuterium MRI: the rungs of two concentric birdcages were azimuthally interleaved with each other for better decoupling, and the two coils were tuned to 400.3 and 61.4 MHz for 1 H/2 H resonance at 9.4 T. Compared to a commercially available coil, the proposed 1 H/2 H RF coil provides reasonable transmission efficiency and imaging signal-to-noise ratio (SNR); the relationships among imaging parameters such as SNR, voxel size, and deuterium oxide concentrations have been quantitatively studied, and the linear correlation results together with the spectroscopic data in vivo indicate its feasibility in deuterium metabolic imaging (DMI) in vivo. Our study indicates that using the birdcage design for MRI signal excitation combined with surface coil array for signal reception can facilitate DMI investigations more effectively towards future pre-clinical and clinical applications. As a noninvasive method by measuring nonhydrogen nuclear deuterium signals to reflect metabolite information, DMI will feature prominently in future precision medicine through the whole process of diagnosis, treatment, and prognosis. © 2021 Bioelectromagnetics Society.
Related Papers
- → Characterization and evaluation of a flexible MRI receive coil array for radiation therapy MR treatment planning using highly decoupled RF circuits(2018)45 cited
- → A Preliminary Study for Reference RF Coil at 11.7 T MRI: Based on Electromagnetic Field Simulation of Hybrid-BC RF Coil According to Diameter and Length at 3.0, 7.0 and 11.7 T(2022)10 cited
- → Analytical approach to noncircular section birdcage coil design: Verification with a Cassinian oval coil(2004)15 cited
- Fabrication of a Staircase Coil with Improved SNR and Image Uniformity by Structural Changes of a Conventional Birdcage Coil at 1.5T MRI(2003)
- → Double-crossed radiofrequency coil with improved uniformity for rodent MRI at 7 T(2022)