The JAK/STAT pathway and Drosophila development
BioEssays2001Vol. 23(12), pp. 1138–1147
Citations Over TimeTop 10% of 2001 papers
Abstract
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling.
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