Alternative splicing and evolution

Citations Over TimeTop 10% of 2003 papers

Abstract

Alternative splicing is a critical post-transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms. It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint.

Related Papers

• → The importance of being divisible by three in alternative splicing(2005)67 cited
• → Alternative splicing produces structural and functional changes in CUGBP2(2012)17 cited
• Repositioning of an alternative exon sequence of mouse IgM pre-mRNA activates splicing of the preceding intron.(1991)
• → P3‐120: Mis‐splicing of Tau Exon 2 and Exon 10 in myotonic dystrophy brain would result from different mechanisms(2011)
• → Characterization of the mechanisms behind the alternative splicing of the mutually exclusive exons 18N and 18A in the sodium channel gene SCN8A and mutually exclusive exons 5N and 5A in the soldium channel gene SCN9A(2011)