Determination of clomipramine by flow‐injection analysis with acidic potassium permanganate–formic acid chemiluminescence detection
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Abstract
A sensitive and simple chemiluminescent (CL) method for the determination of clomipramine has been developed by combining the flow-injection analysis (FIA) technique, which is based on the CL intensity generated from the redox reaction of potassium permanganate (KMnO(4))-formic acid in sulphuric acid (H(2)SO(4)) medium. Under the optimum conditions, the linear range for the determination of clomipramine was 0.04-4 µg/mL, with a correlation coefficient of 0.9988 (n = 10) and a detection limit of 0.008 µg/mL (3σ), and the relative standard deviation (RSD) for 2.0 µg/mL clomipramine (n = 11) is 1.26%. The proposed method has been successfully applied to the determination of the studied clomipramine in pharmaceutical preparations. The possible reaction mechanism is discussed.
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