Multicentre cohort study to define and validate pathological assessment of response to neoadjuvant therapy in oesophagogastric adenocarcinoma
British journal of surgery2017Vol. 104(13), pp. 1816–1828
Citations Over TimeTop 10% of 2017 papers
Fergus Noble, Megan Lloyd, Richard Turkington, Ewen A. Griffiths, Maria O’Donovan, J. Robert O’Neill, S Mercer, Simon L. Parsons, Rebecca C. Fitzgerald, Tim Underwood, A Noorani, Rachael Fels Elliott, Zarah Abdullahi, Rachel de la Rue, Jan Bornschein, Shona MacRae, Barbara Nutzinger, Nicola Grehan, Gianmarco Contino, Jason Crawte, Paul A. Edwards, Ahmad Miremadi, Shalini Malhotra, Annette Hayden, Rob F. Walker, Christopher J. Peters, G Hannah, Richard Hardwick, Jim Davies, Hugo Ford, David Gilligan, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Nicholas Carroll, Damien McManus, Stephen J. Hayes, Yeng Ang, Shaun R. Preston, Sarah Oakes, Izhar Bagwan, Richard J.E. Skipworth, Vicki Save, Ted R. Hupp, Susana Puig, M Bedford, Philippe Tanière, J Whiting, James Byrne, Jamie Kelly, Jack Owsley, Charles Crichton, H. Barr, Neil A. Shepherd, Oliver Old, Jesper Lagergren, J Gossage, Andrew Davies, Fuju Chang, Janine Zylstra, Grant Sanders, Richard Berrisford, Christopher Harden, David Bunting, Michael Lewis, E Cheong, Bhaskar Kumar, James H. Saunders, Irshad Soomro, Ravinder Vohra, John P. Duffy, Philip Kaye, Anna M. Grabowska, Laurence Lovat, Rehan Haidry, Victoria Eneh, Laszlo Igali, I. Welch, Michael Scott, Sharmila Sothi, Sari Suortamo, Suzy Lishman, Duncan Beardsmore, Rupesh Sutaria, Maria Secrier, Matthew Eldridge, Lawrence Bower, Andy G. Lynch, Simon Tavaré
Abstract
A clinically meaningful local response to neoadjuvant chemotherapy was restricted to the small minority of patients (14·8 per cent) with TRG 1-2. Among local non-responders, a subset of patients (21·3 per cent) derived benefit from neoadjuvant chemotherapy by lymph node downstaging and their survival mirrored that of local responders.
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