Low-fat/high-fibre diet prehabilitation improves anastomotic healing via the microbiome: an experimental model
Citations Over TimeTop 10% of 2019 papers
Abstract
The adverse effects of chronic feeding of a WD on the microbiota and anastomotic healing can be prevented by a short course of SD in mice. Surgical relevance Worldwide, enhanced recovery programmes have developed into standards of care that reduce major complications after surgery, such as surgical-site infections and anastomotic leak. A complementary effort termed prehabilitation includes preoperative approaches such as smoking cessation, exercise and dietary modification. This study investigated whether a short course of dietary prehabilitation in the form of a low-fat/high-fibre composition can reverse the adverse effect of a high-fat Western-type diet on anastomotic healing in mice. Intake of a Western-type diet had a major adverse effect on both the intestinal microbiome and anastomotic healing following colonic anastomosis in mice. This could be reversed when mice received a low-fat/high-fibre diet before operation. Taken together, these data suggest that dietary modifications before major surgery can improve surgical outcomes via their effects on the intestinal microbiome.
Related Papers
- → Strength of microvascular anastomoses: Comparison between the unilink anastomotic system and sutures(1989)49 cited
- → Healing of colonic anastomoses(1991)26 cited
- Anastomotic stricture with the EEA stapler after colorectal operation in the dog.(1992)
- Neovascularization of canine sutured and stapled small intestinal anastomoses.(1993)
- → The application of microvascular anastomotic device in microvascular anastomosis with diameter discrepancy(2014)