Development and validation of an RP‐HPLC‐UV method for the determination of BOL‐303225‐A, a new coumarin‐based anti‐inflammatory drug, in rat plasma

Citations Over TimeTop 22% of 2007 papers

Abstract

A simple and rapid high-performance liquid chromatographic method was developed and validated for the analysis in rat plasma of BOL-303225-A, a new coumarin-based anti-inflammatory drug. Liquid-liquid extraction was used for sample preparation. Chromatographic separation was achieved on a C(18) column using acetonitrile and water containing 1% triethylamine pH 3.5, adjusted with orthophosphoric acid (35.5:64.5 v/v) as mobile phase. The UV detector was set at 324 nm. The method proved to be linear (r(2) > 0.99) and precise (RSD < 7%) over the concentration range 29-940 ng/mL, and was suitable for the support of pharmacokinetic studies in rats.

Related Papers

• → Hydrothermal Synthesis of CeO2-SnO2 Nanoflowers for Improving Triethylamine Gas Sensing Property(2018)69 cited
• → A highly selective and fast-responding triethylamine sensor based on Mo-SnO2 nanomaterials(2022)22 cited
• → Transport processes in binary and ternary mixtures containing water, triethylamine and urea. Part 1.—Intradiffusion and viscosity coefficients(1973)14 cited
• → Salt-base equilibrium and fluorescence of 3,4,5,3′,4′,5′-hexamethyl and 4,4′-dicarbethoxy-3,5,3′,5′-tetramethyl dipyrrylmethene hydrochlorides in the presence of triethylamine(1991)1 cited
• CARBONYL TO THIOCARBONYL CONVERSIONS USING TERTIARY AMINE-SOLUBILISED PHOSPHOROUS PENTA SULPHIDE(2013)