The Basis of Cognitive and Behavioral Dysfunction in Amyotrophic Lateral Sclerosis
Brain and Behavior2024Vol. 14(11), pp. e70115–e70115
Citations Over TimeTop 13% of 2024 papers
Alexander Bampton, Caroline McHutchison, Kevin Talbot, Michael Benatar, Alexander G. Thompson, Martin R. Turner
Abstract
Longitudinal studies have been helpful in identifying several potential correlates of cognitive and behavioral dysfunction but have frequently been confounded by selection bias and inappropriate testing platforms. This review provides a framework for more robust assessment of clinicopathological associations of neuropsychological abnormalities in ALS in the future, advocating for greater utilization of pre-symptomatic C9orf72 repeat expansion-carrying cohorts.
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