Pretreatment of rat bone marrow mesenchymal stem cells with a combination of hypergravity and 5‐azacytidine enhances therapeutic efficacy for myocardial infarction
Biotechnology Progress2010Vol. 27(2), pp. 473–482
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Shukuan Ling, Rui Wang, Zhongquan Dai, Jielin Nie, Honghui Wang, Yingjun Tan, Hongqing Cao, Zeng-ming Huang, Yu‐Min Wan, Yinghui Li
Abstract
The biological ex vivo cardiomyogenic differentiation of adult BMSCs with hypergravity and 5-Aza prior to their transplantation is feasible and appears to improve their in vivo cardiac differentiation as well as the functional recovery in a rat model of the infarcted myocardium.
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