Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma
Cancer Communications2021Vol. 41(6), pp. 492–510
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Quanli Zhang, Run Shi, Yongkang Bai, Lijuan Meng, Jingwen Hu, Hongyu Zhu, Tongyan Liu, Xiaomeng De, Siwei Wang, Jie Wang, Lin Xu, Guoren Zhou, Rong Yin
Abstract
MND1, KLF6, and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD. MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients.
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