Identification of immune‐activating metabolite for enhancing T cell therapy of cancer
Cancer Communications2021Vol. 41(7), pp. 535–537
Citations Over Time
Abstract
In this Research Highlight, we summarized the results from a study by Wu et al. published in Nature Cell Biology which uncovered that asparagine (Asn), a non-essential amino acid in mammalians, is able to enhance the TCR-mediated activation and efficacy of CD8+ T cells towards tumour through lymphocyte-specific protein tyrosine kinase (LCK) signalling. This study provides insights into the physiological function of Asn in T cell activation and effector functions, showing the encouraging possibility of key metabolites for empowering cancer immunotherapy.
Related Papers
- → Safety testing of metabolites: Expectations and outcomes(2008)39 cited
- → Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens(2023)7 cited
- → The origin of CD4−CD8−TCRαβ+ thymocytes: a model based on T-cell receptor avidity(1995)43 cited
- → Metabolism of the neuroleptic agent zetidoline in the rat and the dog.(1984)4 cited