Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site‐specific metastasis patterns reflecting their clinical origin
Cancer Medicine2021Vol. 10(23), pp. 8604–8613
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Henrik Aasrum Svendsen, Torstein R. Meling, Vigdis Nygaard, Stein Waagene, Hege Russnes, Siri Juell, Siril G. Rogne, Jens Pahnke, Eirik Helseth, Øystein Fodstad, Gunhild M. Mælandsmo
Abstract
The present work demonstrates that human brain-metastatic melanoma cells injected intracardially in mice had retained inherent characteristics also in reproducing interaction with subtle microenvironmental brain tissue compartment-specific features. The models offer new possibilities for investigating tumor- and host-associated factors involved in determining tissue specificity of brain metastasis.
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