Are de novo rea(21;21) chromosomes really de novo?
Clinical Case Reports2015Vol. 3(10), pp. 786–789
Citations Over TimeTop 10% of 2015 papers
Bérénice Herve, Thibaud Quibel, Stéphane Taieb, Mireille Ruiz, Denise Molina‐Gomes, François Vialard
Abstract
We report a rare case of recurrent trisomy 21 caused by an isochromosome 21q and what is very likely to be maternal germ-line cell mosaicism. Over 90% of cases of rob(21;21) reported in the literature are due to an isochromosome 21q, with a risk of recurrence of more than 10%.
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