Asymmetric reduction of β‐ketoesters and chiral β‐iminoesters: Impact of a α‐quaternary stereocenter
Chirality2010Vol. 23(3), pp. 265–271
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Hadia Almahli, Frédéric Hendra, Claire Troufflard, Christian Cavé, Delphine Joseph, Sandrine Delarue‐Cochin
Abstract
Diastereomeric reduction of nonactivated, hindered β-keto and chiral β-iminoesters are described. The influence of a α-stereocontrolled center on the efficiency and stereoselectivity of the reduction was studied. Reaction conditions were optimized to synthesize β-hydroxy- and β-aminoesters in good yields. In the case of chiral β-iminoesters, influence of matched/mismatched diastereomeric pairs has been assessed.
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