Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct‐analysis‐in‐real‐time Coupled to Time‐of‐flight Mass Spectrometry
ChemMedChem2006Vol. 1(7), pp. 702–705
Citations Over TimeTop 10% of 2006 papers
Facundo M. Fernández, Robert B. Cody, Michael D. Green, Christina Y. Hampton, Rose McGready, Sivong Sengaloundeth, Nicholas J. White, Paul N. Newton
Abstract
Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown).
Related Papers
- → Rapid determination of 5-hydroxymethylfurfural by DART ionization with time-of-flight mass spectrometry(2013)32 cited
- → Recent application of direct analysis in real time mass spectrometry in plant materials analysis with emphasis on traditional Chinese herbal medicine(2023)9 cited
- → Comprehensive comparison of ambient mass spectrometry with desorption electrospray ionization and direct analysis in real time for direct sample analysis(2019)17 cited
- → Nitrogen direct analysis in real time time‐of‐flight mass spectrometry (N 2 DART‐TOFMS) for rapid screening of forensic drugs(2019)13 cited
- → Ambient Ionization for the Detection of Chemical Warfare Agents and Related Chemistries(2020)