Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors
ChemMedChem2007Vol. 2(7), pp. 987–991
Citations Over TimeTop 13% of 2007 papers
Antonello Mai, Sérgio Valente, Donghang Cheng, Andrea Perrone, Rino Ragno, Silvia Simeoni, Gianluca Sbardella, Gerald Brosch, Angela Nebbioso, Mariarosaria Conte, Lucia Altucci, Mark T. Bedford
Abstract
Coding control: Protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) are epigenetic enzymes involved in regulation of gene expression and cellular processes. A new series of histone/protein methyltransferase inhibitors based on the 1,5-diphenyl-1,4-pentadien-3-one scaffold is reported. The described compounds showed various degrees of selectivity against the tested PRMTs (PRMT1 and CARM1) and HKMT (SET7).
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