The Role of Target Binding Kinetics in Drug Discovery
ChemMedChem2015Vol. 10(11), pp. 1793–1796
Citations Over TimeTop 10% of 2015 papers
Abstract
Traditionally structure-activity/affinity relationships (SAR) have dominated research in medicinal chemistry. However, structure-kinetics relationships (SKR) can be very informative too. In this viewpoint we explore the molecular determinants of binding kinetics and discuss challenges for future binding kinetics studies. A scheme for future kinetics-directed drug design and discovery is also proposed.
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