Calcium Coordination Solids for pH‐Triggered Release of Olsalazine
Citations Over Time
Abstract
Abstract Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H 4 olz), an anti‐inflammatory compound used for treatment of ulcerative colitis. The materials include one‐dimensional Ca(H 2 olz)⋅4 H 2 O chains, two‐dimensional Ca(H 2 olz)⋅2 H 2 O sheets, and a three‐dimensional metal‐organic framework Ca(H 2 olz)⋅2DMF (DMF= N , N ‐dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H 2 olz) phase when exposed to aqueous HCl. The compounds Ca(H 2 olz)⋅ x H 2 O ( x =0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH‐neutral intestines. All three calcium materials exhibited a delayed release of olsalazine relative to Na 2 (H 2 olz), the commercial formulation, illustrating how formulation of a drug within an extended coordination solid can serve to tune its solubility and performance.
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