The Role of the Phosphorus Atom in Drug Design
ChemMedChem2018Vol. 14(2), pp. 190–216
Citations Over TimeTop 10% of 2018 papers
Abstract
Abstract Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus‐containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups.
Related Papers
- → Exploring the Isoreticular Continuum between Phosphonate- and Phosphinate-Based Metal–Organic Frameworks(2022)19 cited
- → Cross-bridged cyclam derivatives with bis(phosphinate) and phosphinate–phosphonate pendant arms (cb-BPC) as chelators for copper radioisotopes(2024)1 cited
- → Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates(1999)26 cited
- → Phosphonate vs. phosphinate elimination during olefination of aldehydes(1993)6 cited
- → ChemInform Abstract: PHOSPHATE, PHOSPHONATE, AND PHOSPHINATE COMPLEXES OF SOME METAL(II) TETRAFLUOROBORATES(1982)