Cover Feature: Concentration‐Dependent Inhibition of Mesophilic PETases on Poly(ethylene terephthalate) Can Be Eliminated by Enzyme Engineering (ChemSusChem 8/2023)
ChemSusChem2023Vol. 16(8)
Luisana Avilán, Bruce R. Lichtenstein, Gerhard König, Michael Zahn, Mark D. Allen, Liliana Oliveira, Matilda Clark, Victoria Bemmer, Rosie Graham, Harry P. Austin, Graham Dominick, Christopher W. Johnson, Gregg T. Beckham, J.E. McGeehan, Andrew R. Pickford
Abstract
The Cover Feature shows the effect of concentration dependent inhibition of natural enzymes that break down poly(ethylene terephthalate) (PET), a polymer widely used in consumer packaging and which contributes to plastic pollution. Mesophilic enzymes (depicted on the right), such as IsPETase from Ideonella sakaiensis, are inhibited as the enzyme concentration increases. In contrast, enzymes engineered to be thermostable (depicted on the left), are not susceptible to this inhibition and can degrade PET at high enzyme concentration. More information can be found in the Research Article by L. Avilan et al. Image credit: Scivetica/Rita Clare.
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