An optimised whole blood interleukin‐2 release assay is more sensitive than interferon‐γ ELIS pot for detecting and quantifying gluten‐specific CD 4 + T‐cell responses in coeliac disease
Clinical & Translational Immunology2025Vol. 14(12), pp. e70063–e70063
Citations Over TimeTop 11% of 2025 papers
Abstract
The IL-2 WBA provides superior sensitivity over IFN-γ ELISpot for detecting gluten-specific T cells. It can measure the functional blockade of HLA and accurately reflects gluten peptide immunogenicity hierarchies. The IL-2 WBA supports immunomonitoring and T-cell epitope mapping in CD and offers broad research and clinical application beyond CD.