Identification of MRAP protein family as broad‐spectrum GPCR modulators
Clinical and Translational Medicine2022Vol. 12(11), pp. e1091–e1091
Citations Over TimeTop 13% of 2022 papers
Meng Wang, Xiaozhu Wang, Bopei Jiang, Yue Zhai, Jihong Zheng, Yang Liu, Xiaolu Tai, Yunpeng Li, Shaliu Fu, Jing Xu, Xiaowei Lei, Zhe Kuang, Cong Zhang, Cong Zhang, Xuanxuan Bai, Mingyu Li, Tao Zan, Shen Qu, Qingfeng Li, Chao Zhang, Chao Zhang
Abstract
Collectively, our study has comprehensively elucidated the complex GPCR networks in two major endocrine organs and redefined the MRAP protein family as broad-spectrum GPCR modulators. MRAP proteins not only serve as a vital endocrine pivot on the regulation of global GPCR activities in vivo that could explain the composite physiological phenotypes of the MRAP2 null murine model but also provide us with new insights of the phenotyping investigation of GPCR-MRAP functional complexes.
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