Immune landscape and the key role of APOE+ monocytes of lupus nephritis under the single‐cell and spatial transcriptional vista
Clinical and Translational Medicine2023Vol. 13(4), pp. e1237–e1237
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Youzhou Tang, Ying Zhang, Xinyu Li, Ruoyao Xu, Ying Ji, Jishi Liu, Jianye Liu, Quan Zhuang, Hao Zhang
Abstract
In LN, APOE+ Mono are compensatorily elevated, with decreased antigen presenting ability and reduced secretion of interferons. The lymphangiogenesis in LN prompts the trafficking of Mono/MΦ in LN kidney.
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