Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A
Clinical and Translational Medicine2021Vol. 11(5), pp. e402–e402
Citations Over TimeTop 10% of 2021 papers
Yongchao Zhao, Jingjing Hu, Xiaolei Sun, Kun Yang, Lebing Yang, Lingqiu Kong, Beijian Zhang, Fuhai Li, Chaofu Li, Bei Shi, Kai Hu, Aijun Sun, Junbo Ge
Abstract
We demonstrate that ALKBH5 is a negative regulator of post-ischemic angiogenesis via post-transcriptional modulation and destabilization of WNT5A mRNA in an m6A-dependent manner. Targeting ALKBH5 may be a potential therapeutic option for ischemic diseases, including peripheral artery disease.
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