Rebalancing TGF‐β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis
Clinical and Translational Medicine2021Vol. 11(7), pp. e410–e410
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Yang Yang, Mayu Sun, Weida Li, Chaobao Liu, Zheshun Jiang, Pengfei Gu, Jingquan Li, Wei Wang, Rongli You, Qian Ba, Xiaoguang Li, Hui Wang
Abstract
Our results unveil the approach of CKI in rebalancing TGF-β/Smad7 signaling in HSCs to protect against hepatic fibrosis and hepatocarcinogenesis in both preclinical and clinical studies. Our study suggests that CKI can be a candidate for treatment of hepatic fibrosis and related oncogenesis.
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