WHITE MATTER ABNORMALITIES IN CHILDREN AND ADOLESCENTS WITH OBSESSIVE-COMPULSIVE DISORDER: A DIFFUSION TENSOR IMAGING STUDY
Depression and Anxiety2012Vol. 29(9), pp. 780–788
Citations Over TimeTop 10% of 2012 papers
Rajan Nishanth Jayarajan, Ganesan Venkatasubramanian, Biju Viswanath, Y.C. Janardhan Reddy, Shoba Srinath, Mandapatti Krishnamurthy Vasudev, Channapatna R. Chandrashekar
Abstract
Our findings suggest involvement of multiple WM tracts in juvenile OCD. In addition to the widely proposed hypothesis of orbitofrontal-striato-thalamo-cortical circuitry deficits in the development of OCD, our findings suggest involvement of additional brain regions, possibly parietal cortex, lateral prefrontal cortex, and limbic system. The widespread differences in WM among cases and controls also points to the possibility of underlying myelination changes.
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