RELATIONSHIP BETWEEN THE CORTICAL THICKNESS AND SERUM CORTISOL LEVELS IN DRUG-NAÏVE, FIRST-EPISODE PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A SURFACE-BASED MORPHOMETRIC STUDY
Depression and Anxiety2015Vol. 32(9), pp. 702–708
Citations Over TimeTop 21% of 2015 papers
Xiaodan Liu, Shingo Kakeda, Keita Watanabe, Reiji Yoshimura, Osamu Abe, Satoru Ide, Kenji Hayashi, Asuka Katsuki, Wakako Umeno-Nakano, Rieko Watanabe, Issei Ueda, Junji Moriya, Jun Nakamura, Yukunori Korogi
Abstract
In the early stage of MDD, the thickness of the lateral orbitofrontal cortex was significantly reduced, and also showed a significant inverse correlation with the serum cortisol levels. Since the lateral orbitofrontal cortex contains a high concentration of glucocorticoid receptor, glucocorticoid receptor-mediated signaling transductions could contribute to neurotoxicity, which might occur when there are high cortisol levels in patients with MDD.
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