Low omega‐3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder
Depression and Anxiety2022Vol. 39(5), pp. 407–418
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Sofia Cussotto, Inês Delgado, Giovanni Oriolo, Jonas Kemper, Diane Begarie, Sandra Dexpert, Julie Sauvant, Marion Leboyer, Bruno Aouizerate, Rocı́o Martı́n-Santos, Martin Schaefer, Lucile Capuron
Abstract
These results show that baseline levels of PUFAs predict later response to standard antidepressants in depressed subjects. They suggest that PUFA intake and/or metabolism represent a novel modifiable tool for the management of unresponsive depressed patients.
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