Association of disease course and brain structural alterations in major depressive disorder
Depression and Anxiety2022Vol. 39(5), pp. 441–451
Citations Over TimeTop 10% of 2022 papers
Hannah Lemke, Lina Romankiewicz, Katharina Förster, Susanne Meinert, Lena Waltemate, Stella M. Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J. Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai G. Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinsträter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadić, Tilo Kircher, Udo Dannlowski
Abstract
This study shows that a more severe and chronic lifetime disease course in MDD is associated with reduced volume in brain regions relevant for executive and cognitive functions and emotion regulation in a large sample of patients representing the broad heterogeneity of MDD disease course. These findings were only partly influenced by other clinical characteristics (e.g., remission status, psychopharmacological treatment).
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