White matter microstructure disruption in early stage amyloid pathology
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring2021Vol. 13(1), pp. e12124–e12124
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Lyduine E. Collij, Silvia Ingala, Herwin Top, Viktor Wottschel, Kristine Stickney, Jori Tomassen, Elles Konijnenberg, Mara ten Kate, Carole H. Sudre, Isadora Lopes Alves, Maqsood Yaqub, Alle Meije Wink, Dennis van ‘t Ent, Philip Scheltens, Bart N.M. van Berckel, Pieter Jelle Visser, Frederik Barkhof, Anouk den Braber
Abstract
Early amyloid deposition is associated with changes in WM microstructure. The non-linear relationship might reflect multiple stages of axonal damage.
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