Plasma p‐tau181/Aβ 1‐42 ratio predicts Aβ‐PET status and correlates with CSF‐p‐tau181/Aβ 1‐42 and future cognitive decline
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring2022Vol. 14(1), pp. e12375–e12375
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Christopher Fowler, Erik Stoops, Stephanie R. Rainey‐Smith, Eugeen Vanmechelen, Jeroen Vanbrabant, Nele Dewit, Kimberley Mauroo, Paul Maruff, Christopher C. Rowe, Jürgen Fripp, Qiao‐Xin Li, Pierrick Bourgeat, Steven Collins, Ralph N. Martins, Colin L. Masters, James D. Doecke
Abstract
Plasma p-tau181/Aβ1-42 ratio predicted both Aβ-PET status and cognitive decline, demonstrating potential as both a diagnostic aid and as a screening and prognostic assay for preclinical AD trials.
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