Fine‐needle aspiration cytology diagnosis of metastatic gastrointestinal stromal tumor in the liver: A report of three cases
Citations Over Time
Abstract
Gastrointestinal stromal tumor (GIST) is the designation for a major subset of gastrointestinal mesenchymal tumors that histologically, immunocytochemically, and genetically differ from leiomyomas, leiomyosarcomas, and schwannomas. GISTs derive from the interstitial cells of Cajal and, in addition to variable expression of smooth muscle and neural markers, they characteristically express CD34 and CD117. The cytological appearance, including immunocytochemical and mutational analysis of c-kit gene in primary GIST has been well described. To our knowledge, only two cases of metastatic GIST diagnosed by fine-needle aspiration (FNA) have been reported. We illustrate three cases of metastatic GIST in the liver. Two cases had no prior history of gastrointestinal tumor and the third case had a 4-yr previous history of duodenal tumor. Consistent immunocytochemistry and ultrastructual studies supported the diagnosis of GIST. We emphasize that in the appropriate clinical and radiological setting, a confident diagnosis of GIST can be established by FNA of metastatic lesions.
Related Papers
- → Contribution of Interstitial Cells of Cajal to Gastrointestinal Stromal Tumor Risk(2021)13 cited
- → [To improve the understanding of CD117-negative gastrointestinal stromal tumor].(2019)1 cited
- Expression and significance of CD_(117),CD_(34) in gastrointestinal stromal tumors(2011)
- Expression and Significance of DOG-1 in Gastrointestinal Stromal Tumors(2012)
- → Testicular Gastrointestinal Stromal Tumor (GIST): An Extremely Unusual Secondary of Gastric Primary(2018)