Dysplastic cells in cytological cervical samples show a high incidence of chromosomal abnormalities
Citations Over Time
Abstract
Chromosomal abnormalities are frequent in most cervical cancers. Amplifications of both the 3q26 (TERC) and 8q24 (MYC) loci have been shown to be prevalent in both high-grade lesions and invasive cervical carcinoma. Most of these studies have looked at either the histological sample or at the entire cytological population of cells. We have developed a Papanicolaou (Pap) destaining method that allows for the accurate analysis of individual cells that were previously identified by cytopathology as dysplastic. The application of fluorescence in situ hybridization (FISH) was then implemented to determine the chromosomal status of the dysplastic cells in the samples and correlate the two events. Chromosomal abnormality is over a thousand times more frequent in dysplastic cells compared with their morphologically normal counterparts.
Related Papers
- → Guidelines of the Papanicolaou Society of Cytopathology for the Examination of Cytologic Specimens Obtained from the Respiratory Tract(1999)53 cited
- → Pancreaticobiliary tract cytology: Journey toward “Bethesda” style guidelines from the Papanicolaou Society of Cytopathology(2014)17 cited
- → The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology(2018)11 cited
- Guidelines of the Papanicolaou Society of Cytopathology for the examination of cytologic specimens obtained from the respiratory tract. The Papanicolaou Society of Cytopathology Task Force on Standards of Practice.(1999)
- → Erratum: Pitman MB and Layfield LJ. Guidelines for pancreaticobiliary cytology from the Papanicolaou Society of Cytopathology: A review. Cancer Cytopathology doi: 10.1002/cncy.21427.(2014)