Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID‐19 mRNA vaccine
Diabetes/Metabolism Research and Reviews2021Vol. 38(1), pp. e3465–e3465
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Mikiko Watanabe, Angela Balena, Dario Tuccinardi, Rossella Tozzi, Renata Risi, Davide Masi, Alessandra Caputi, Rebecca Rossetti, Maria Elena Spoltore, Valeria Filippi, Elena Gangitano, Silvia Manfrini, Stefania Mariani, Carla Lubrano, Andrea Lenzi, Claudio Maria Mastroianni, Lucio Gnessi
Abstract
Central obesity, hypertension, and smoking are associated with lower Ab titres following COVID-19 vaccination. Although it is currently impossible to determine whether lower SARS-CoV-2 Abs lead to higher likelihood of developing COVID-19, it is well-established that neutralizing antibodies correlate with protection against several viruses including SARS-CoV-2. Our findings, therefore, call for a vigilant approach, as subjects with central obesity, hypertension, and smoking could benefit from earlier vaccine boosters or different vaccine schedules.
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