No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility
Diabetes/Metabolism Research and Reviews2006Vol. 22(5), pp. 356–360
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Rebecca Pask, Jason D. Cooper, Neil Walker, Sarah Nutland, Jayne Hutchings, David B. Dunger, Sergey Nejentsev, John A. Todd
Abstract
We found no evidence for a major effect of C1167T or C(-262)T on T1D susceptibility in two large sample collections. Limited statistical evidence of an association at C1167T in USA families and C(-262)T in UK families was found, but these results are likely to be false positives. The previously reported association of these SNPs may also have been a false positive, or a population specific association in Russians from Moscow.
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