Insulin analogues display IGF‐I‐like mitogenic and anti‐apoptotic activities in cultured cancer cells
Diabetes/Metabolism Research and Reviews2009Vol. 25(1), pp. 41–49
Citations Over TimeTop 1% of 2009 papers
Abstract
Glargine, detemir and lispro, unlike regular insulin, exhibit in vitro proliferative and anti-apoptotic activities in a number of cancer cell lines. These actions resemble some of the effects of IGF-I, a growth factor involved in cancer initiation and progression. Insulin had no increased IGF-I activity. The specific receptor/s involved in mediating analogues actions remains to be identified.
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