Between a rock and a hard place: Regulation of mineralization in the periodontium

Citations Over TimeTop 10% of 2022 papers

Abstract

Summary The periodontium supports and attaches teeth via mineralized and nonmineralized tissues. It consists of two, unique mineralized tissues, cementum and alveolar bone. In between these tissues, lies an unmineralized, fibrous periodontal ligament (PDL), which distributes occlusal forces, nourishes and invests teeth, and harbors progenitor cells for dentoalveolar repair. Many unanswered questions remain regarding periodontal biology. This review will focus on recent research providing insights into one enduring mystery: the precise regulation of the hard‐soft tissue borders in the periodontium which define the interfaces of the cementum–PDL–alveolar bone structure. We will focus on advances in understanding the molecular mechanisms that maintain the unmineralized PDL “between a rock and a hard place” by regulating the mineralization of cementum and alveolar bone.

Related Papers

• → Central Role of Pyrophosphate in Acellular Cementum Formation(2012)144 cited
• → Cementum Attachment Protein Enriches Putative Cementoblastic Populations on Root Surfaces in vitro(2000)42 cited
• → Development and Structure of Cementum(2022)4 cited
• → Models for the Study of Cementogenesis(1995)18 cited
• [Cementum formation in rat molar roots].(2000)