Heparin impairs skeletal muscle glucose uptake by inhibiting insulin binding to insulin receptor
Endocrinology Diabetes & Metabolism2021Vol. 4(3), pp. e00253–e00253
Citations Over Time
Canjun Zhu, Zhiyue Xu, Yexian Yuan, Tao Wang, Chang Xu, Cong Yin, Peipei Xie, Pingwen Xu, Hui Ye, Nirali Patel, Sarah Schaul, Lina Wang, Xiaotong Zhu, Songbo Wang, Ping Gao, Qianyun Xi, Yongliang Zhang, Gang Shu, Qingyan Jiang
Abstract
Heparin reduced insulin binding to its receptor by interacting with insulin and inhibited insulin-mediated activation of the PI3K/Akt signalling pathway in skeletal muscle, which leads to impaired glucose uptake and hyperglycaemia.
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