Duration and onset of action of high dose U‐500 regular insulin in severely insulin resistant subjects with type 2 diabetes
Endocrinology Diabetes & Metabolism2018Vol. 1(4), pp. e00041–e00041
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Rupendra T. Shrestha, Anjali Kumar, Abdisa Taddese, Ameer Khowaja, Amir Moheet, Evan Olawsky, Lynn E. Eberly, Elizabeth R. Seaquist
Abstract
The duration of action of U-500 increases when dose is increased from 100 to 200 units. Neither dose of U-500 insulin has an onset of action before 2.5 hours after administration. This suggests that U-500 should not be used as a premeal bolus insulin to lower glucose two hours after a meal and that dosing intervals might need to be extended as dose is increased to avoid hypoglycaemia.
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