Efficacy and Safety of Orforglipron in Obese Adults With or Without Diabetes: A Systematic Review and Meta‐Analysis
Endocrinology Diabetes & Metabolism2025Vol. 8(6), pp. e70134–e70134
Ravi S. Pandey, Mahnoor Jan, Akram Mohammad, Khawaja Arham Jawaid, Muhammad Asif Naveed, M. Abid, Abdelrahman Amir, Shafique Ahmed, Muhammad Safiullah, Muhammad Imaz Bhatti, S Y Iftikhar, Muhammad Nabeel Saddique, Widyan Alfalh, Razali Omar, Husam Abu Dawood
Abstract
Orforglipron significantly improved glycemic and lipid parameters in patients with obesity, demonstrating dose-dependent efficacy with maximal benefits at higher doses. While gastrointestinal tolerability remains a clinically important limitation requiring mitigation strategies, orforglipron represents a promising oral therapeutic option for comprehensive obesity and metabolic management.