Empagliflozin Inhibits Na+/H+ Exchanger Activity in Human Atrial Cardiomyocytes
ESC Heart Failure2020Vol. 7(6), pp. 4429–4437
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Maximilian Trum, Johannes Riechel, Simon Lebek, Steffen Pabel, Samuel Sossalla, Stephan Hirt, Michael Arzt, Lars S. Maier, Stefan Wagner
Abstract
This is the first study systematically analysing NHE1 expression in human atrial and ventricular myocardium of HF patients. We show that empagliflozin inhibits NHE in human cardiomyocytes. The extent of NHE inhibition was comparable with cariporide and may potentially contribute to the improved outcome of patients in clinical trials.
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