Rapid Sequencing of Split‐and‐Mix Peptide Receptor Libraries – Identification of Binding Partners for Val‐Val‐Ile‐Ala in Aqueous Solution

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Abstract

Abstract Split‐and‐mix peptide libraries have been encoded by capping cleavable, laddered sequences with p ‐bromobenzoic acid, allowing rapid analysis of the cleaved ladder fragments by mass spectrometry. The encoding methodology has been applied to the synthesis of libraries of peptide receptors and a library of tripeptides functionalised with a bicyclic guanidinium unit has been successfully screened to identify binding partners for Val‐Val‐Ile‐Ala, the C‐terminal tetrapeptide sequence of the amyloid‐β protein, Aβ(1–42). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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