Conditional expression of HIV‐1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex‐dependent manner
European Journal of Pain2020Vol. 24(8), pp. 1609–1623
Citations Over TimeTop 13% of 2020 papers
Deniz Bağdaş, Jason J. Paris, Moriah Carper, Rachel Wodarski, Andrew S.C. Rice, Pamela E. Knapp, Kurt F. Hauser, M. Imad Damaj
Abstract
The ability of Tat to decrease oedema, paw swelling, and limit allodynia suggests a sequel of events in which Tat-induced functional deficits precede the onset of mechanical hypersensitivity. Moreover, HIV-1 Tat attenuated responses to inflammatory and neuropathic insults in a sex-dependent manner. HIV-1 Tat appears to directly contribute to HIV sensory neuropathy and reveals sex differences in HIV responsiveness and/or the underlying peripheral neuroinflammatory and nociceptive mechanisms.
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