Human surrogate models of central sensitization: A critical review and practical guide
European Journal of Pain2021Vol. 25(7), pp. 1389–1428
Citations Over TimeTop 10% of 2021 papers
Charles Quesada, Anna Kostenko, Idy H. T. Ho, Caterina Leone, Zahra Nochi, Alexandre Stouffs, Matthias Wittayer, Ombretta Caspani, Nanna Brix Finnerup, André Mouraux, Gisèle Pickering, Irene Tracey, Andrea Truini, Rolf‐Detlef Treede, Luís García‐Larrea
Abstract
Being able to mimic aspects of pathological pain directly in humans has a huge potential to understand pathophysiology and provide animal research with translatable biomarkers for drug development. One group of human surrogate models has proven to have excellent predictive validity: they respond to clinically active medications and do not respond to clinically inactive medications, including some that worked in animals but failed in the clinics. They should therefore inform basic research for new drug development.
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