Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers–Danlos syndrome, hypermobility type
European Journal of Pain2016Vol. 20(8), pp. 1319–1325
Citations Over TimeTop 10% of 2016 papers
Giulia Di Stefano, Claudia Celletti, Ralf Baron, Marco Castori, Manuela Di Franco, S. La Cesa, Caterina Leone, Alessia Pepe, G. Cruccu, Andrea Truini, Filippo Camerota
Abstract
While the lack of somatosensory nervous system damage is incompatible with neuropathic pain as the mechanism underlying pain in JHS/EDS-HT, the lowered cold and heat pain thresholds and increased wind-up ratio imply that pain in JHS/EDS-HT might arise through central sensitization. Hence, this connective tissue disorder and fibromyalgia share similar pain mechanisms. WHAT DOES THIS STUDY ADD?: In patients with JHS/EDS-HT, the persistent nociceptive input due to joint abnormalities probably triggers central sensitization in the dorsal horn neurons and causes widespread pain.
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