Genetic analysis workshop II: Segregation and three‐locus linkage analysis
Genetic Epidemiology1984Vol. 1(2), pp. 161–165
Abstract
Data stimulated for Genetic Analysis Workshop II were analyzed using PAP. Segregation analysis showed a simple recessive mode of inheritance for data set 2 while no conclusions could be made about the mode of inheritance for data set 3. Pairwise linkage analysis suggested three linkage groups, but three-locus analysis did not provide strong evidence for the gene order within these groups. For three of the four three-locus comparisons performed, three-locus analysis suggested the simulated order. In only one case did the pairwise analysis suggest the simulated order, indicating the necessity for multi-locus analysis for gene order.
Related Papers
- → Temporal expression of candidate genes at the Co-1 locus and their interaction with other defense related genes in common bean(2019)31 cited
- Confirmation of linkage and refinement of the RP28 locus for autosomal recessive retinitis pigmentosa on chromosome 2p14-p15 in an Indian family.(2004)
- Mapping of the gene for X-linked amelogenesis imperfecta by linkage analysis.(1990)
- Linkage studies in a new X-linked myopathy, suggesting exclusion of DMD locus and tentative assignment to distal Xq.(1988)
- Confirmation of a third locus, at 2p, for autosomal recessive limb-girdle muscular dystrophy indicates that at least 4 genes are responsible for this condition(1994)