A 24‐week, double‐blind, placebo‐controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease—pilot study
International Journal of Geriatric Psychiatry2002Vol. 17(3), pp. 270–278
Citations Over TimeTop 10% of 2002 papers
Abstract
Donepezil Hydrochloride administered once a day appears to be generally well tolerated and safe in DS adults who have AD. There is some possible efficacy in the treatment of symptoms of mild to moderate Alzheimer's disease in this population, although the sample size of this study was too small for statistical significance. It is recommended that donepezil, with the appropriate precautions, should be considered for the treatment of AD in adults with DS as deemed by a specialist.
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