What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia
International Journal of Geriatric Psychiatry2003Vol. 18(11), pp. 988–993
Citations Over TimeTop 10% of 2003 papers
Thaı́s Minett, Alan Thomas, Lucy Wilkinson, Sarah Daniel, Jonathan Sanders, Jonathan L. Richardson, Elizabeth Littlewood, Pat Myint, Jane Newby, Ian G. McKeith
Abstract
Our results suggest that treatment with donepezil improves cognition and hallucinations without increasing parkinsonian symptoms, and its sudden withdrawal is usually detrimental, producing acute cognitive and behavioural decline. Although recommencement on donepezil appears to reverse this deterioration we do not advise its abrupt discontinuation in this population.
Related Papers
- → Donepezil use in US nursing homes(2004)20 cited
- → The Relationship Between Donepezil and Behavioral Disturbances in Patients With Alzheimer's Disease(2000)70 cited
- → The Relationship Between Donepezil and Behavioral Disturbances in Patients With Alzheimer's Disease(2000)18 cited
- → Effect of add‐on administration of kamikihito with donepezil monotherapy in a patient with Alzheimer's disease(2020)1 cited
- Clinical observation of effect of donepezil in treating Alzhemer's disease(2010)