Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage‐independent growth in human tonsil epithelial cells
Head & Neck2007Vol. 30(2), pp. 139–147
Citations Over TimeTop 13% of 2007 papers
William C. Spanos, Jeremy Geiger, Mary E. Anderson, George F. Harris, Aaron Bossler, Russell B. Smith, Aloysius J. Klingelhutz, Johan Lee
Abstract
The mechanism of oncogenic transformation by E6 in HTEC's is dependent on the PDZ binding motif. Identification of pathways affected by the interaction of E6 and PDZ domain containing proteins will further our understanding of how HPV causes HNSCC and will provide potential therapeutic targets.
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