Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis†

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Abstract

This is the first direct evidence that noncancerous, adult human livers harbor several types of cells that produce and/or respond to Hh ligands. Such Hh-responsive cells accumulate during the fibroproliferative response to chronic cholestatic liver injury, suggesting a role for Hh signaling in this process.

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